Bioorganic and Medicinal Chemistry

Biography

Seema P Mengshetti received her B.S. and M.S. degree in chemistry from the Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad, Maharashtra, India in 2002 and 2004 respectively. She completed her Ph.D. in 2013 in the group of Dr. Vaijayanti Kumar, Organic Chemistry Division, National Chemical Laboratory, Pune, Maharashtra. Her thesis focused on synthesis and biophysical properties of Nucleic acid analogues bearing 5-atom achiral amide- and chiral D/L-amino acid-derived linkages, as well as Nucleic acid analogues bearing 4’-modified nucleosides for their potential therapeutic application in the field of antisense drug strategy. After completion of her PhD, she worked as a Research Associate in the same group of Dr. Vaijayanti Kumar. Currently, Dr. Seema works as a postdoctoral research associate in Dr. Raymond Schinazi’s multidisciplinary research group at Laboratory of Biochemical Pharmacology, Emory University School of Medicines, Atlanta USA. Her research involves design and synthesis of nucleotides, nucleosides & corresponding phosphate analogs and/prodrugs for the treatment of HIV, HCV, HBV & other newly emerging viruses and nucleic acid analogs/mimics, oligonucleotides and their biophysical studies for their potential use as an antisense drugs. She also works on synthesis of triphosphates for enzyme studies. She is a member of the American Chemical Society (ACS), Royal Society of Chemistry (RSC), The International Society of Nucleosides, Nucleotides and Nucleic acid (IS3NA), International Society for Antiviral Research (ISAR), Indian Society of Chemist and Biologist (ISCB), and Chemical Research Society of India (CRSI). She keeps her intellectual interests alive as an editorial board member for several organic chemistry, medicinal chemistry journals. She also serves as a reviewer for many international journals (RSC, ELESVIER, Springer Open, ACS) spanning research areas; synthetic medicinal chemistry, nucleoside and nucleotide chemistry and biochemical sciences.

Research Interest

Dr.seema thesis focused on synthesis and biophysical properties of Nucleic acid analogues bearing 5-atom achiral amide- and chiral D/L-amino acid-derived linkages, as well as Nucleic acid analogues bearing 4’-modified nucleosides for their potential therapeutic application in the field of antisense drug strategy Her research involves design and synthesis of nucleotides, nucleosides & corresponding phosphate analogs and/prodrugs for the treatment of HIV, HCV, HBV & other newly emerging viruses and nucleic acid analogs/mimics, oligonucleotides and their biophysical studies for their potential use as an antisense drugs. She also works on synthesis of triphosphates for enzyme studies.