Doaa Ibrahim
Ain Shams University, Egypt
Title: : Possible impact of Dapagliflozin on micro RNAs regulation and cell apoptosis in gentamicin induced nephrotoxicity in rats
Biography
Biography: Doaa Ibrahim
Abstract
Drug-Induced Kidney Injury (DIKI) is a serious complication associated with higher probabilities of developing progressive chronic kidney disease or end-stage renal diseases. Understanding the molecular disarrangement caused by DIKI would pave the way for a new class of therapeutics to relieve the damage. Yet, another approach to ameliorate DIKI is identifying sensitive and specific biomarkers that outperform the current diagnostic approach like serum creatinine and facilitate early diagnosis. MicroRNAs (miRNAs), a class of non-coding RNAs are increasingly being recognized to have a regulatory role in gene expression and signaling pathways thereby making them novel therapeutic targets. Kidney function, oxidative stress and apoptosis markers, miRNAs expression in serum and renal biopsies were examined in gentamicin induced nephrotoxicity Dapagliflozin (DAPA) was found to improve kidney function, oxidative stress markers, decrease apoptosis of renal tubular cells and regulate certain miRNAs expression, indicating protective effect against Gentamicin (GNT) induced nephrotoxicity.