World Congress on Bioorganic and Medicinal Chemistry November 12-13, 2018 Dubai, UAE

Medicinal biochemistry is that branch of drugs involved with the biochemistry and metabolism of human health and sickness. The medical chemist is trained in the operation and management of clinical biochemistry laboratories. The medical chemist directs clinical laboratories, consults, diagnoses and treats patients with a range of metabolic disorders and biochemical abnormalities. Medicinal biochemistry deals with the functioning of traditional and pathologic organisms from a biochemical purpose of view. It provides a whole understanding of all chemical processes occurring and related to living cells at the molecular level that's associated with drug action. It conjointly helps to acquire data on the adverse effects, molecular targets, & characterization of medicine or different chemical substance within the living cells & organisms.

Chemical biology is the study of the chemicals and chemical reactions involved in biological life processes, incorporating the disciplines of bioorganic chemistry, biochemistry, cell biology, and pharmacology. Chemicals including natural small molecules, such as lipids, carbohydrates, and metals, or non-natural probe or drug molecules are used to gain insight into biological problems at a mechanistic level. There are some biological problems demand molecular and quantitative answers that can only be supplied by tools and approaches derived from chemistry such as single-molecule measurements, single-cell imaging, and the use of exogenous molecules to modulate the activity of cellular components. While yeast metabolic engineering has focused on assembling pathways in the cell cytosol.

Structural Biochemistry is a sub-division of biochemistry that mainly focuses on the structural characteristics of the molecules within cells and other made up of living organisms. The main area is focused on the structural basis of fundamental biological processes. It involves the study of the structure of macromolecules. It includes methods for structure determination and huge data of structural information. Additionally deals with the interactions amongst totally different cell parts as well as macromolecules like nucleic acids, proteins, lipids, amino acids, and carbohydrates. Molecular biochemistry has big wide to capture the array of chemistry, physics, medicine, and biology.

The term biological target is also used in pharmaceutical research to describe the natural protein in the body whose activity is modified by a drug resulting in a specific effect at the specific site, which may be an adequate therapeutic effect or an unnecessary adverse effect. Biological target identification and validation are some of the maximum essential steps in developing a new drug. Drug target validation includes proving that DNA, RNA, or a protein molecule is at once concerned in an ailment process and may be an appropriate goal for the improvement of a brand new therapeutic drug. Targeted drug delivery systems have been developed to optimize regenerative methods. 

Drug discovery and design are the processes of finding new drugs by design, depending on their biological targets. It is also known as a rational drug design. Drug discovery is an effort to develop a new drug molecule by applying varieties of methodologies of design. This procedure includes the identification of drug targets, candidates, Synthesis, Screening, physical and chemical characterization and assays. Drug development is the process of manufacturing and marketing the biologically active compound by drug design by observing the pharmacokinetic, pharmacodynamic, toxicological and various clinical parameters are included.

Drug delivery is the method of intended a pharmaceutical compound to develop a therapeutic effect for human or animal use. It is an integrated concept with dosage form and route of administration. Nasal and pulmonary routes of drug delivery techniques are gaining importance for the treatment of human diseases. These methods are concerned with the drug release profile, absorption, distribution and elimination for the advancement of the product viability and safety and patient convenience and compliance. To lower the drug degradation, adverse effects, and side effects. To increase drug bioavailability and bioequivalence to prevent harmful toxic-effects. Many drug delivery and drug targeting techniques are currently under development.

Current advancement in Medicinal Pharmacy efforts is moving towards the more targeted approach. Target identification and validation are the first major stages of this process. It involves demonstration of relevance and confirmation of target protein in a disease which can then be translated to animal models and this may involve the latest in gene expression techniques and gene targeting methods. An advance in Medicinal pharmacy covers the principles, methods, and technologies that the pharmaceutical industry uses to turn that candidate molecule into the final drug dosage form. Optimizing the therapeutic performance of the molecule which includes designing, characterizing, testing the drug in clinical trials, and manufacturing the final product.

The global chemical industry is very large and competitive. The industry products account for a major share of the overall global chemicals industry. The global chemical industry consists of a very diverse and complicated range of products. In terms of revenue, it is one of the world’s largest markets World Congress on Bioorganic and Medicinal Chemistry 2018 welcomes all the leading industries and eminent leaders to join us and share their ideas for enhancing the market of Chemical Industry and factors affecting the strength of competition in the global chemicals market.

Carbon is one of the unique element to form a wide variety of compounds that contain long chains and/or rings of carbon atoms. Organic molecules are the most complex chemical structures found in living organisms. Despite their size and complexity, these biological molecules follow the same chemical principles as simpler organic molecules. Organic chemistry is that the study of chemical compounds containing a minimum of one bond between an atom of a chemical compound and a metal complex. Organic chemistry combines aspects of Bioorganic Chemistry, Inorganic Chemistry, and Medicinal Chemistry. Organic chemistry unit of measurement is widely used in the same chemical process. The carbon atoms combine with other elements in a number of different ways to through special bonds like covalent bonds to form a large number of compounds which have a strong influence on nature, and specific behavior and properties can be applied to medical, health, industrial and commercial fields. Organic chemistry mainly aims to provide progress in the fields of Medicinal chemistry,  Forensic chemistry, Asymmetric synthesis, organometallic chemistry, bioorganic chemistry, Heterocyclic chemistry and Analytical methods of Inorganic chemistry.

Bioorganic chemistry is a scientific subject that combines both natural chemistry and biochemistry whereas Medicinal chemistry is the field which specializes in small natural molecules that encompasses synthetic natural chemistry and elements of herbal products and computational chemistry in close combination with enzymology, chemical and structural biology, together aiming on the development and discovery of new healing agents. Organic chemistry is used to explain how enzymes catalyze the reactions of metabolic pathways and why metabolites react the manner they do. It is focusing to expand organic-chemical research on structures, synthesis, and kinetics in a biological direction.

Medicinal chemistry and pharmaceutical chemistries are disciplines at the intersection of chemistry, especially synthetic organic chemistry, and pharmacology and various other biological specialties, where they are involved with design, chemical synthesis and development for the market of pharmaceutical agents or bioactive molecules. It involves chemical aspects of identification, and then systematic through synthetic alteration of new chemical entities to make them suitable for intended use. At the biological interface, Medicinal chemistry combines to form a set of highly interdisciplinary organic, physical computational emphases alongside biological areas. 

Pharmacokinetic is the quantitative analysis of drug movement in, through and out of the body. The intensity of the effect is related to the concentration of the drug at the site of action. Pharmacokinetics also includes the study of the time course of drug absorption, distribution, metabolism, and excretion. Clinical pharmacokinetics is the application of pharmacokinetic principles to the safe and effective therapeutic management of drugs in an individual patient. Primary goals of clinical pharmacokinetics include enhancing safety, efficacy and reducing the toxicity of a patient’s drug therapy. The development of strong correlations between drug concentrations and their pharmacologic responses has enabled clinicians to apply pharmacokinetic principles to actual patient situations. 

Pharmacodynamics is the study of the physiological and biological effect of drugs. The effect of a drug present at the site of achievement is determined by that drug’s binding to a receptor. Receptors may be present on neurons in the central nervous system to depress pain sensation, on cardiac muscle to affect the intensity of contraction, or even within bacteria to disrupt maintenance of the bacterial cell wall.

Organic chemical engineering is a branch that applies physical sciences (physical science and organic natural science), life sciences (microbiology and organic chemistry), together with connected arithmetic and financial matters to deliver, change, transport, and appropriately utilize chemicals and materials.

Pharmaceutical chemistry is the study of drug compounds, and it involves drug development process. This includes drug discovery, delivery, absorption, metabolism, distribution, and excretion. There are elements of biomedical analysis, pharmacology, pharmacokinetics, and pharmacodynamics. Pharmaceutical chemistry work is usually done in laboratory conditions it mainly involves cures and remedies for disease, analytical techniques, pharmacology, metabolism, quality control, quality assurance, and drug chemistry. Pharmaceutical chemistry leads to careers in drug development, pharmaceutical industries, and research facilities. Pharmaceutical chemists are involved in the development and assessment of therapeutic compounds. Every chemical that is synthesized must be tested for biological activity. In vitro testing involves biological assays outside a living system that means in laboratory conditions. The field of pharmaceutical chemistry is unique and it involves vast areas of expertise. Analytical chemists can isolate and identify active components from the plant and other natural resources. Pharmaceutical chemists evaluate the bioactivity of drugs and drug metabolites. Pharmacologists can assess drug purity, safety and efficacy adverse effects of drug therapy. When a drug has been approved for human studies, clinicians and physicians should monitor patient’s compliance with treatment with the new drug compound. The impact of pharmaceutical chemistry in the development of drug compounds is very high and advanced methods are now available for development of the drug are done by using pharmaceutical chemistry.